Ig. Keskin et al., Tracheal reconstruction using alcohol-stored homologous cartilage and autologous cartilage in the rabbit model, INT J PED O, 56(3), 2000, pp. 161-167
Citations number
12
Categorie Soggetti
Otolaryngology
Journal title
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
Objective: Reconstruction of laryngotracheal stenosis continues to pose a s
ignificant challenge. Cartilage grafts have been in use for almost a centur
y, but despite good clinical results, many questions concerning the surviva
l and growth of implanted cartilage persist. To reduce donor site morbidity
, the use of homologous cartilage has been investigated. This study compare
d alcohol-stored homologous auricular cartilage with autologous auricular c
artilage for anterior graft laryngotracheal reconstruction in a rabbit mode
l, Methods: Autologous and alcohol preserved homologous auricular cartilage
was transplanted to the resected anterior tracheal wall of the twenty New
Zealand rabbits. Rabbits were sacrificed 6 weeks after surgery and histolog
ic analysis was performed on the implanted cartilage grafts. Results: The a
utografts were significantly more likely than the homografts to demonstrate
Viable cells (95% vs. 30%, P < 0.05) and less likely to exhibit significan
t resorption, fibrosis or necrosis (P < 0.05). Resorption and necrosis were
most common in areas of trauma to the graft. Complete epithelialization oc
curred in all of the autografts but in only 65% of the homografts (P < 0.05
). New cartilage formation and integration of the implanted grafts was poor
with both types of grafts. Conclusion: Autologous cartilage appears to hav
e better survival than alcohol preserved homologous cartilage when used for
anterior graft laryngotracheal reconstruction in a rabbit model. (C) 2000
Elsevier Science Ireland Ltd. All rights reserved.