T. Anttila et al., Serotypes of Chlamydia trachomatis and risk for development of cervical squamous cell carcinoma, J AM MED A, 285(1), 2001, pp. 47-51
Citations number
42
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Context Human papillomavirus (HPV) infection has been established as a caus
e of cervical cancer. Epidemiologic studies suggest that Chlamydia trachoma
tis infection. also confers increased risk for cervical squamous cell carci
noma (SCC). Whether this risk is serotype-specific is unknown.
Objective To study the association between exposure to different C trachoma
tis serotypes and subsequent development of cervical SCC.
Design and Setting Longitudinal, nested case-control study within a cohort
of 530000 women who provided samples to serum banks in Finland, Norway, and
Sweden, The data files were linked to respective national cancer registrie
s.
Subjects One hundred twenty-eight women who had developed invasive cervical
SCC at least 12 months following serum donation. Each case had 3 matched c
ontrols.
Main Outcome Measure Risk for the development of cervical SCC by Ige antibo
dies to 10 different C trachomatis serotypes, adjusted for antibodies to HP
V types 16, 18, and 33 and for serum cotinine levels.
Results Of specific C trachomatis serotypes, serotype CI was most strongly
associated with SCC (adjusted odds ratio [OR], 6.6; 95 % confidence interva
l [CI], 1.6-27.0), Other serotypes associated with SCC were I (OR, 3.8; 95%
CI, 1.3-11.0) and D (OR, 2.7; 95% CI, 1.3-5.6). Presence of serum IgG anti
bodies to more than 1 serotype increased the adjusted ORs for SCC (P<.001 f
or trend).
Conclusions Chlamydia trachomatis serotype C is most strongly associated wi
th subsequent development of cervical SCC. Increasing numbers of exposures
to different C trachomatis serotypes also increases risk, Our results stren
gthen the evidence that there is a link between past C trachomatis infectio
n and cervical SCC.