Ca2+-sensitization of contraction in the h1 calponin-deficient smooth muscle

Authors
Yoshimoto, R Hori, M Takahashi, K Taniguchi, S Katsuki, M Ozaki, H Karaki, H
Citation
R. Yoshimoto et al., Ca2+-sensitization of contraction in the h1 calponin-deficient smooth muscle, JPN J PHARM, 84(4), 2000, pp. 474-475
Citations number
10
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JAPANESE JOURNAL OF PHARMACOLOGY
ISSN journal
00215198 → ACNP
Volume
84
Issue
4
Year of publication
2000
Pages
474 - 475
Database
ISI
SICI code
0021-5198(200012)84:4<474:COCITH>2.0.ZU;2-5
Abstract
Role of h1 calponin on Ca2+-sensitivity of smooth muscle contraction was in vestigated using h1 calponin gene-deficient mice (CP -/-) and wild type mic e (CP+/+). PGF(2 alpha) induced a comparable force in intact aorta of CP +/ + and CP -/-. DPB showed similar effects to PGF(2 alpha). In membrane-perme abilized ileal smooth muscle, PDBu enhanced Ca2+-sensitivity of contraction comparably in CP +/+ and CP -/-. GTP gamma -S showed similar effects. Our results suggest that h1 calponin does not regulate Ca2+-sensitivity in the contractile mechanism of smooth muscle.