R. Driouich et al., Separation and determination of haloperidol, parabens and some of their degradation products by micellar electrokinetic chromatography, J CHROMAT A, 903(1-2), 2000, pp. 271-278
A micellar solution containing phosphate buffer, anionic surfactant, and wa
ter-miscible organic solvent was employed as a migration solution for the s
eparation and the quantification of eleven analytes by micellar electrokine
tic chromatography (MEKC): the analytes examined were haloperidol, methylpa
raben, ethylparaben, n-propylparaben, iso-propylparaben, n-butylparaben, is
o-butylparaben, sec-butylparaben, 4-(4-chlorophenyl)-4-hydroxypiperidine, 4
-fluorobenzoic acid and 4-hydroxybenzoic acid. In order to provide good sep
aration between micelle and haloperidol, which showed strongest interaction
with the micelle among the analytes, surfactant concentrations and organic
modifier percentages were studied with phosphate buffer at pH 7.0. All the
analytes were successfully resolved when 10 mM sodium dodecylsulfate and 1
5% ethanol were contained in the migration solution; the time window was ve
ry wide in the range from 14.8 to 65.5 min. Optimized applied voltage at 30
kV and capillary temperature at 45 degreesC enable analyze all compounds i
n less than 17 min with the best resolution, the shorter migration time win
dow, the highest precision and lowest detection limit. (C) 2000 Elsevier Sc
ience B.V. All rights reserved.