Breathing system filters are recommended for use during general anaest
hesia. Manufacturers of gas sampling equipment recommend that gas is s
ampled from the 'machine side' of these filters, thereby avoiding cont
amination of the sampling line and waterlogging in the case of heat an
d moisture exchangers. The aim of this study was to investigate differ
ences between the measured end-tidal carbon dioxide values at either s
ide of the filter. Fifteen adults were studied during mechanical venti
lation and 15 during spontaneous ventilation under general anaesthesia
. End-tidal carbon dioxide values were significantly lower at the mach
ine side of the filter in both groups (p = 0.00001). The measurement e
rror induced by the inclusion of the breathing system filter was signi
ficantly greater in the spontaneously breathing group (p = 0.0004).