Classification of premalignant and malignant lesions developing in the ratmammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea
Hj. Thompson et al., Classification of premalignant and malignant lesions developing in the ratmammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea, J MAMMARY G, 5(2), 2000, pp. 201-210
Premalignant and malignant stages of mammary carcinogenesis can be rapidly
induced by injecting female rats i.p. with 1-methyl-1-nitrosourea (MNU)(3)
at 21 days of age. In this paper, the characteristics of this model are bri
efly reviewed and the histology of the lesions induced is presented and com
pared to those that occur in humans. Malignant mammary lesions induced in r
ats injected with MNU at 21 days of age are compared with the lesions that
develop when MNU is administered to 50-day-old female rats.