Classification of premalignant and malignant lesions developing in the ratmammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea

Authors
Thompson, HJ Singh, M McGinley, J
Citation
Hj. Thompson et al., Classification of premalignant and malignant lesions developing in the ratmammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea, J MAMMARY G, 5(2), 2000, pp. 201-210
Citations number
16
Categorie Soggetti
da verificare
Journal title
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
ISSN journal
10833021 → ACNP
Volume
5
Issue
2
Year of publication
2000
Pages
201 - 210
Database
ISI
SICI code
1083-3021(200004)5:2<201:COPAML>2.0.ZU;2-7
Abstract
Premalignant and malignant stages of mammary carcinogenesis can be rapidly induced by injecting female rats i.p. with 1-methyl-1-nitrosourea (MNU)(3) at 21 days of age. In this paper, the characteristics of this model are bri efly reviewed and the histology of the lesions induced is presented and com pared to those that occur in humans. Malignant mammary lesions induced in r ats injected with MNU at 21 days of age are compared with the lesions that develop when MNU is administered to 50-day-old female rats.