Detection of doxorubicin cardiotoxicity by using iodine-123 BMIPP early dynamic SPECT: Quantitative evaluation of early abnormality of fatty acid metabolism with the Rutland method

Background, To evaluate the possibility of predicting the development of do xorubicin-induced cardiomyopathy, we performed quantitative assessment of t he early kinetics of iodine-123 beta-methyl-iodophenyl-pentadecanoic acid ( I-123 BMIPP) by means of dynamic myocardial SPECT. Methods, Thirty-six patients with various malignancies were examined, I-123 BMIPP dynamic myocardial SPECT was performed before chemotherapy, after ch emotherapy, or both. Immediately after the injection of I-123 BMIPP (111 MB q), 30-second dynamic SPECT data were acquired successively for 15 minutes. The left ventricular (LV) myocardium was divided into 8 segments in short- axial and vertical slices, By using the time-activity curve (TAC) of each m yocardial segment [Mo(t)] as an output function and the TAC of the LV cavit y [B(t)] as an input function, the Rutland equation, Mo(t)/B(t)= F + K inte gralB(t)dt/B(t), was used as a means of assessing all segments. Results, Mo(t)/B(t) showed a good linear correlation with integralB(t)dt/B( t) from 30 seconds to 4 minutes in all 456 segments. The mean K value of 8 LV segments was significantly lower after chemotherapy than before chemothe rapy (0.071 +/- 0.019 [n = 21] vs 0.095 +/- 0.025 [n = 36], P <.001). In 21 patients in whom dynamic SPECT was performed both before and after chemoth erapy, the mean K values of left ventricle showed a significant decrease, f rom 0.101 +/- 0.024 to 0.071 + 0.019 (P <.0001). The fractional change in t he value of K after chemotherapy showed a significant linear correlation wi th the administered dose of doxorubicin (r = 0.648, P <.002). Conclusion. I-123 BMIPP dynamic myocardial SPECT may be clinically useful, because it permits the early detection of doxorubicin-induced cardiomyopath y.