Transfer of radionuclides across skin barriers of animal skin models in vitro

Radioactive skin contamination with radionuclides in ionic forms after the permeation across skin models was studied in vitro. Using animal skin model s of 5-day-old rat and 9-day-old rat, either intact or stripped, it was fou nd that besides the transepidermal also the transfolicular flux can be impo rtant. Stratum corneum was found to be the principal permeation barrier in all cases. The study of penetration - time profiles revealed that permeated amounts were proportional to time in the case of Cs-137(+) and Co-60(2+), but they showed a local maximum in the case of Pm-147(3+).