Effect of NSAID administration on creatinine clearance in healthy dogs undergoing anaesthesia and surgery

Thirty healthy male dogs were randomly assigned to receive carprofen (4 mg/ kg intravenously), ketoprofen (2 mg/kg intravenously) or saline (0.2 ml/kg intravenously) at induction of anaesthesia for castration surgery. A routin e castration was undertaken and a buccal mucosal bleeding time was assessed at the completion of surgery. Twenty-four hours after surgery a 24-hour en dogenous creatinine clearance study was undertaken. Buccal mucosal bleeding time was not significantly different between the three groups. Creatinine clearance was significantly lower (P less than or equal to 0.01) in the two groups of dogs that received a non-steroidal anti-inflammatory drug compar ed with that in the dogs that received sterile saline. There was no signifi cant difference between the carprofen and ketoprofen groups with respect to creatinine clearance.