M. Uchiyama et al., Treatment of childhood renal cell carcinoma with lymph node metastasis: Two cases and a review of literature, J SURG ONC, 75(4), 2000, pp. 266-269
Standard treatment for renal cell carcinoma (RCC) is radical nephrectomy wi
th lymph node dissection. Stages I and II have encouraging prognoses, but S
tage III with regional lymph node metastasis can be unfavorable. Adjuvant t
herapy for pediatric patients with advanced RCC with lymph node involvement
or metastatic lesion has not been defined. Advanced pediatric RCC is repor
ted in two patients (boys, aged 6 and 9 years: Stage IIIs, Robson; Stage IU
, and IV, pTNM classification) treated by nephrectomy and lymph node dissec
tion followed by postoperative interferon-a (IFN), that can be used as an a
djuvant therapy with side effects such as fever, bone marrow suppression, o
r decreased liver function. One is doing well for 7 years, another is suffe
red from lung metastases at 3 years after surgery. Although immunotherapy i
s expected to improve survival in pediatric patients with advanced RCC, sur
gical resection of renal and meta; static tumors remains the standard treat
ment. (C) 2000 Wiley-Liss, Inc.