K. Takamine et al., The involvement of the neuronal Golgi apparatus and trans-Golgi network inthe human olivary hypertrophy, J NEUR SCI, 182(1), 2000, pp. 45-50
We studied the Golgi apparatus (GA) and trans-Golgi network (TGN) in the hu
man olivary hypertrophy by immunohistological methods with organelle specif
ic antibodies against the medial cisternae of the organelle (MG160) and the
trans-Golgi network (TGN46). The GA and TGN of enlarged neurons in the inf
erior olivary nuclei in the early stages after central tract lesions lost t
he normal network-like configuration, and they were reduced to numerous sma
ll disconnected granules (fragmentation). In chronic stages after lesions,
the GA and TGN of vacuolated or enlarged neurons showed a variety of morpho
logical profiles, such as normal-looking patterns, fragmentation, reduction
in number, and aggregation around nuclei or at a distance in the cytoplasm
. In patients with multiple system atrophy, the GA and TGN of the neurons i
n the inferior olivary nuclei showed almost similar findings to those seen
in the chronic stages after brainstem lesions. These results suggest that t
he GA and TGN are affected in degenerating neurons by anterograde transneur
onal mechanisms. (C) 2000 Elsevier Science B.V. All rights reserved.