Nitroprusside in resuscitation or major torso trauma

Objective: Patients with thoracic aortic injury (TAI) usually have sustaine d other major trauma, and may require aggressive shock resuscitation. In th e 24 hours after aortic repair and during resuscitation, our cardiothoracic surgeons request intravenous nitroprusside to maintain mean arterial press ure (MAP) less than 90 mm Hg to minimize bleeding at the repair. We compare d the resuscitation response of patients who sustained major torso trauma ( MTT) and TAI with that of patients who had MTT with no TAI to determine whe ther nitroprusside can effectively central MAP during resuscitation and whe ther use of nitroprusside, because of its peripheral vasodilatory, effects, is associated with a favorable resuscitation response. Methods: During the 9-month study period, 11 patients who sustained TAI and 38 patients who sustained MTT with no TAI met multiple organ failure risk/ shock criteria and were resuscitated by a standardized protocol emphasizing volume loading and hemoglobin replacement to maintain systemic oxygen deli very index (Do(2)I) greater than or equal to 600 mL O-2/min-m(2) for the Fi rst 24 intensive care unit hours, Fur TAI patients, postoperative managemen t included intravenous nitroprusside infusion titrated by the bedside nurse to maintain mean arterial pressure (MAP) less than 90 mm Bg during the sam e 24 hours. Data were obtained prospectively during resuscitation. Retrospe ctively, the resuscitation response of TAI and non-TAI patients was compare d. Results: For the TAI group, nitroprusside effectively controlled MAP (range , 77-87 mm Hg); for the non-TAI group, mean MAP exceeded 95 mm Hg within 5 hours, During the first 8 hours, MAP, pulmonary capillary wedge pressure, a nd systemic vascular resistance index were less, and Do(2)I was greater for the TAI than for the non-TAI group. The resuscitation goal of Do(2)I great er than or equal to 600 mL O-2/min-m(2) was attained at 4 hours for the TAI group, and was attained at 12 hours for the non-TAI group. No revisions of aortic repairs were required during or as a result of resuscitation. Conclusion: During aggressive shock resuscitation, control of MAP using nit roprusside is feasible and is associated with a favorable resuscitation res ponse. Nitroprusside may he a useful adjunct during shock resuscitation of MTT as a vasoactive agent that promotes peripheral tissue perfusion.