In vivo selection of T-cell receptor junctional region sequences by HLA-A2human T-cell lymphotropic virus type 1 Tax11-29 peptide complexes

Authors
Saito, M Taylor, GP Saito, A Furukawa, Y Usuku, K Weber, JN Osame, M Bangham, CRM
Citation
M. Saito et al., In vivo selection of T-cell receptor junctional region sequences by HLA-A2human T-cell lymphotropic virus type 1 Tax11-29 peptide complexes, J VIROLOGY, 75(2), 2001, pp. 1065-1071
Citations number
27
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
2
Year of publication
2001
Pages
1065 - 1071
Database
ISI
SICI code
0022-538X(200101)75:2<1065:IVSOTR>2.0.ZU;2-W
Abstract
Using HLA-peptide tetrameric complexes, we isolated human T-cell lymphotrop hic virus type 1 Tax peptide-specific CD8(+) T cells ex vivo. Antigen-speci fic amino acid motifs were identified in the T-cell receptor V beta CDR3 re gion of clonally expanded CD8(+) T cells. This result directly confirms the importance of the CDR3 region in determining the antigen specificity in vi vo.