Possibilities of sterility therapy in a patient with a premature menopausedue to an X-chromosomal anomaly - a case report

Our report concerns a patient with a climacterium praecox and an X-chromoso mal anomaly (86% 46, XX; 7% 47, XXX; 7% 45, X0) desiring to give birth. She conceived once after down-regulation of the gonadotrophins by means of a c yclical hormone replacement therapy followed by gonadotrophin stimulation, as well as a second time under down-regulation with a GnRH-analogue and gon adotrophin stimulation. On the basis of the case report and of the literatu re, a possible interval therapy in such a patient, especially one even with increasing ovarian insufficiency, will be portrayed and discussed. (C) 200 0 Elsevier Science Ireland Ltd. All rights reserved.