Association between Novelty Seeking and the-521 C/T polymorphism in the promoter region of the DRD4 gene

Association between the human personality trait 'Novelty Seeking' and the p olymorphism of the DRD4 gene was first reported by Ebstein(1) and Benjamin( 2) in 1996. This was soon followed by replication studies in various ethnic groups and by studying the role of other neurotransmitter receptor and tra nsporter genes in the genetic determination of human temperament. More rece ntly, several polymorphic sites of the upstream regulatory region of the DR D4 gene have been described.(3) Among these the -521 C/T single nucleotide polymorphism (SNP) was shown to be associated with the Novelty Seeking (NS) scores of the Temperament and Character Inventory (TCI) in a Japanese male population.(4) We have investigated the -521 C/T SNP polymorphism in a Cau casian (Hungarian) population,(5) and here we report a replication of the J apanese findings, in an association study involving 109 healthy Hungarian v olunteers. We found a weak association between NS and CC vs CT or TT genoty pes (P < 0.06). Examination of this relation in male and female sex groups, however, strengthened the association for females (P < 0.01), but showed n o genotypic effect for males.