Two technologies of crop protection are compared, crop protection by pestic
ides and by Genetically Modified Plants (GMPs). The history of pesticides p
rovides lessons relevant to the future of GMPs; (1) high pesticide usage is
counter-productive, (2) the technology requires intensive regulation and (
3) has nonetheless many external effects which strongly reduce its social b
enefits, (4) early calculations on net benefits of pesticides were over-opt
imistic, and (5) intensive use of pesticides made farmers so dependent on t
hem that they lost important options. These lessons are used to construct a
framework for the economic analysis of GMPs which can be applied once suff
icient empirical information becomes available. Conceptually the framework
can be used for a comparison of crop protection strategies indicated as che
mical crop protection, threshold-based crop protection, crop protection by
ecotechnology and organic agriculture. Given the current state of knowledge
on the impact of GMPs where (1) benefits are assumed rather than proven, (
2) regulatory costs are rising and (3) environmental and human health risks
have yet to be fully identified, one conclusion is that ex ante economic a
nalysis which draws upon some of the lessons learned with chemical pesticid
es may help to bridge the gap between the proponents and the opponents of G
MT (Genetic Modification Technology).