Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE

Authors
Morris, HR Vaughan, JR Datta, SR Bandopadhyay, R de Silva, HAR Schrag, A Cairns, NJ Burn, D Nath, U Lantos, PL Daniel, S Lees, AJ Quinn, NP Wood, NW
Citation
Hr. Morris et al., Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE, NEUROLOGY, 55(12), 2000, pp. 1918-1920
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
55
Issue
12
Year of publication
2000
Pages
1918 - 1920
Database
ISI
SICI code
0028-3878(200012)55:12<1918:MSASPA>2.0.ZU;2-A
Abstract
Alpha synuclein, tau, synphilin, and APOE genotypes were analyzed in patien ts with multiple system atrophy (MSA) and progressive supranuclear palsy (P SP) and controls. The predisposing effect of the tau insertion polymorphism to the development of PSP is confirmed. However, no effect of alpha -synuc lein, synphilin, or APOE variability on the development of PSP, or of tan, alpha -synuclein, APOE, or synphilin gene variability on the development of MSA, are demonstrated.