Reversible posterior leukoencephalopathy after combination chemotherapy

Authors
Honkaniemi, J Kahara, V Dastidar, P Latvala, M Hietaharju, A Salonen, T Keskinen, L Ollikainen, J Vahamaki, L Kellokumpu-Lehtinen, P Frey, H
Citation
J. Honkaniemi et al., Reversible posterior leukoencephalopathy after combination chemotherapy, NEURORADIOL, 42(12), 2000, pp. 895-899
Citations number
25
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEURORADIOLOGY
ISSN journal
00283940 → ACNP
Volume
42
Issue
12
Year of publication
2000
Pages
895 - 899
Database
ISI
SICI code
0028-3940(200012)42:12<895:RPLACC>2.0.ZU;2-9
Abstract
We describe a young woman with Burkitt's lymphoma, treated with intravenous adriamycine and cyclophosphamide and intrathecal cytarabine. She developed a reversible posterior leukoencephalopathy syndrome (RPLS) with typical MR I findings. Diffusion-weighted images during the first days after the onset of symptoms predicted a small irreversible lesion in the frontal lobe, ver ified on T2-weighted images 1 month later. The patient showed full recovery after high-dose steroid treatment.