Antisense basic fibroblast growth factor oligonucleotide reduced adhesion of retinal pigment epithelial cells to extracellular matrix molecules and their proliferation

Authors
Rho, SH Yoon, HS Yoo, KW Park, WC Jeong, JH Yoo, YH
Citation
Sh. Rho et al., Antisense basic fibroblast growth factor oligonucleotide reduced adhesion of retinal pigment epithelial cells to extracellular matrix molecules and their proliferation, OPHTHAL RES, 33(1), 2001, pp. 24-30
Citations number
21
Categorie Soggetti
da verificare
Journal title
OPHTHALMIC RESEARCH
ISSN journal
00303747 → ACNP
Volume
33
Issue
1
Year of publication
2001
Pages
24 - 30
Database
ISI
SICI code
0030-3747(200101/02)33:1<24:ABFGFO>2.0.ZU;2-K
Abstract
We investigated the effect of extracellular matrix molecules on the adhesio n of retinal pigment epithelial cells and their subsequent proliferation. F ibronectin, collagen type I and vitronectin enhanced their adhesion and pro liferation. In addition, the effect of basic fibroblast growth factor (bFGF ) on their adhesion and proliferation was studied. bFGF enhanced their adhe sion and proliferation, whereas antisense bFGF reduced their adhesion to an d their proliferation on extracellular matrix molecules. Copyright (C) 2001 S. Karger AG, Basel.