Dp. Cox et al., Ameloblastic carcinoma ex ameloblastoma of the mandible with malignancy-associated hypercalcemia, ORAL SURG O, 90(6), 2000, pp. 716-722
Citations number
22
Categorie Soggetti
Dentistry/Oral Surgery & Medicine
Journal title
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS
Ameloblastoma is a rare, locally destructive, benign neoplasm of the jawbon
es, which arises from epithelium derived from the epithelial components of
the developing tooth. Ameloblastic carcinoma is the term used to designate
any ameloblastoma in which there is histologic evidence of malignancy in th
e primary tumor, regardless of whether it has metastasized. Most ameloblast
ic carcinomas are presumed to have arisen de novo, with few cases of malign
ant transformation of ameloblastoma. being apparent. Hypercalcemia is the m
ost common metabolic complication of malignancy. Although malignancy-associ
ated hypercalcemia is often reported in association with other malignancies
, it is exceedingly unusual in association with ameloblastoma, malignant am
eloblastoma, or amelobtaslic carcinoma. We describe a patient with multiple
recurrences of ameloblastoma, with subsequent malignant transformation pre
senting with malignancy-associated hypercalcemia.