T. Kikusui et al., Involvement of corticotropin-releasing factor in the retrieval process of fear-conditioned ultrasonic vocalization in rats, PHYSL BEHAV, 71(3-4), 2000, pp. 323-328
The role of the corticotropin-releasing factor (CRF) system in the fear-con
ditioned ultrasonic vocalizations (USVs) induced by foot shocks in rats was
investigated. In the acquisition phase of fear conditioning, the intracere
broventricular administration of CRF receptor antagonist alpha -hCRF attenu
ated USV responses related to context memory. Even after experiencing eight
consecutive days of foot-shock challenges, the alpha -hCRF group emitted s
imilar number of USVs as the control group if they were not given the drug.
After the conditioning phase, the groups treated with alpha -hCRF or CRF r
eceptor 1 (CRFR1) antagonist CP-154,526 emitted fewer conditioned USVs than
the control group, although there was no difference in the USVs after the
shock, which reflected physical stress. These results suggest that the cent
ral CRF systems, especially those mediated via CRFR1, are involved in the r
etrieval process, but not the acquisition or retention processes, of fear-r
elated memory. (C) 2000 Elsevier Science Inc. All rights reserved.