Effect of dietary fiber on the activity of intestinal and fecal beta-glucuronidase activity during 1,2-dimethylhydrazine induced colon carcinogenesis

The effects of fiber isolated from black gram (Phaseolus mungo) and Coconut (Cocos nucifera) kernel on the metabolic activity of intestinal and fecal beta glucuronidase activity during 1,2-dimethylhydrazine induced colon carc inogenesis were studied. The results indicated that the inclusion of fiber from black gram and coconut kernel generally supported lower specific activ ities and less fecal output of beta-glucuronidase than did the fiber free d iet. This study suggests that the fibers isolated from coconut or black gra m may potentially play a role in preventing the formation of colon tumors i nduced by the carcinogen 1,2-dimethylhydrazine by reducing the activity of the intestinal as well as fecal beta-glucuronidase.