Gene expression profiles in normal and Otx2(-/-) early gastrulating mouse embryos

Authors
Zakin, L Reversade, B Virlon, B Rusniok, C Glaser, P Elalouf, JM Brulet, P
Citation
L. Zakin et al., Gene expression profiles in normal and Otx2(-/-) early gastrulating mouse embryos, P NAS US, 97(26), 2000, pp. 14388-14393
Citations number
24
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN journal
00278424 → ACNP
Volume
97
Issue
26
Year of publication
2000
Pages
14388 - 14393
Database
ISI
SICI code
0027-8424(200012)97:26<14388:GEPINA>2.0.ZU;2-N
Abstract
The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expr ession profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by u sing a serial analysis of gene expression assay adapted to microdissected s tructures. Among a broader list, the study of six genes found to be differe ntially expressed allows defining a role for Otx2 in the orchestration of c ell movements leading to the adequate organization of the embryo before gas trulation.