CROSS-COUPLING APPROACH TOWARDS DYNEMICIN ANALOGS WITHOUT THE NITROGEN

Authors
BOSSE F TUNOORI AR MAIER ME
Citation
F. Bosse et al., CROSS-COUPLING APPROACH TOWARDS DYNEMICIN ANALOGS WITHOUT THE NITROGEN, Tetrahedron, 53(27), 1997, pp. 9159-9168
Citations number
44
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
27
Year of publication
1997
Pages
9159 - 9168
Database
ISI
SICI code
0040-4020(1997)53:27<9159:CATDAW>2.0.ZU;2-7
Abstract
Utilizing a cross-coupling reaction between the arylstannane 5 and the iodoenone 7, the arylcyclohexenone 8 was prepared. This compound was then transformed into the enediyne aldehydes 16a,b. Treatment of 16a w ith cat. amounts of TBAF gave rise to the macrocyclic dynemicin analog 17a. This was converted to the phenolic enediyne 18. (C) 1997 Elsevie r Science Ltd.