Axillary nodal status continues to be the most statistically significant pr
edictor of survival for patients with breast cancer. Although still providi
ng regional control of axillary disease, axillary dissection is more import
ant as a staging and prognostic tool. Trials are currently underway to inve
stigate the possibility of replacing the current standard treatment of brea
st cancer, axillary lymph node dissection, with the less invasive lymphatic
mapping and sentinel lymph node biopsy. This issue and the technical aspec
ts of sentinel lymph node mapping for breast cancer are discussed in detail
in this article.