Sentinel lymph node (SLN) mapping has been found to be highly effective in
correctly predicting the nodal status for melanoma and for breast cancer. T
his study shows that SLN mapping also is highly successful in colorectal ca
ncer, posing minimal cost and no complications. The procedure accurately de
termines the presence or absence of nodal micrometastasis in more than 96%
of cases. This article reviews the in vivo and ex vivo techniques for SLN m
apping in colorectal cancer, along with its limitations and pitfalls.