First synthesis of a highly strained cyclodeca-1,5-diyne skeleton via intramolecular Sonogashira cross-coupling

Authors
Dai, WM Wu, AX
Citation
Wm. Dai et Ax. Wu, First synthesis of a highly strained cyclodeca-1,5-diyne skeleton via intramolecular Sonogashira cross-coupling, TETRAHEDR L, 42(1), 2001, pp. 81-83
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
1
Year of publication
2001
Pages
81 - 83
Database
ISI
SICI code
0040-4039(20010101)42:1<81:FSOAHS>2.0.ZU;2-C
Abstract
Cyclization of alkenyl bromides 6 and 11 containing a terminal alkyne was a chieved by using an intramolecular cross-coupling reaction catalyzed by Pd( 0) and Cu(I). Under the optimal reaction conditions, cyclodeca-1,5-diyne de rivatives 7 and 12 were obtained in 43 and 28% yields, respectively. (C) 20 00 Elsevier Science Ltd. All rights reserved.