Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol

Authors
Borissow, CN Smith, TK Ferguson, MAJ Brimacombe, JS
Citation
Cn. Borissow et al., Synthesis of 3 '-, 4 '- and 6 '-deoxy and other analogues of D-glucosaminylphosphatidylinositol, TETRAHEDR L, 42(1), 2001, pp. 121-123
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
1
Year of publication
2001
Pages
121 - 123
Database
ISI
SICI code
0040-4039(20010101)42:1<121:SO3'4'>2.0.ZU;2-1
Abstract
Deoxy and other analogues of D-glucosaminylphosphatidylinositol 1 have been synthesised and tested as substrates or inhibitors of a de-N-acetylase and mannosyltransferase (MT-1) involved in the biosynthesis of the glycosylpho sphatidylinositol (GPI) membrane anchor of the parasite Trypanosoma brucei. (C) 2000 Elsevier Science Ltd. All rights reserved.