Ay. Rulev et al., Transformation of alpha-formylated enamines: Synthesis of N,N-disubstituted alpha-amino esters, TETRAHEDR L, 41(52), 2000, pp. 10211-10214
2-Dialkylaminoalkanoic esters are prepared in moderate yield by the reactio
n of N,N-disubstituted 2-amino-2-alkenals with dialkyl phosphonates in the
presence of sodium alkoxide. A mechanism involving an alpha -keto-beta -ami
nophosphonate as an intermediate is proposed. (C) 2000 Elsevier Science Ltd
. All rights reserved.