Transformation of alpha-formylated enamines: Synthesis of N,N-disubstituted alpha-amino esters

Authors
Rulev, AY Larina, LI Voronkov, MG
Citation
Ay. Rulev et al., Transformation of alpha-formylated enamines: Synthesis of N,N-disubstituted alpha-amino esters, TETRAHEDR L, 41(52), 2000, pp. 10211-10214
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
52
Year of publication
2000
Pages
10211 - 10214
Database
ISI
SICI code
0040-4039(200012)41:52<10211:TOAESO>2.0.ZU;2-K
Abstract
2-Dialkylaminoalkanoic esters are prepared in moderate yield by the reactio n of N,N-disubstituted 2-amino-2-alkenals with dialkyl phosphonates in the presence of sodium alkoxide. A mechanism involving an alpha -keto-beta -ami nophosphonate as an intermediate is proposed. (C) 2000 Elsevier Science Ltd . All rights reserved.