Synthesis of conformationally constrained peptides via solid-phase incorporation of the constraints

Authors
Toth, GK Kele, Z Fulop, F
Citation
Gk. Toth et al., Synthesis of conformationally constrained peptides via solid-phase incorporation of the constraints, TETRAHEDR L, 41(51), 2000, pp. 10095-10098
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
51
Year of publication
2000
Pages
10095 - 10098
Database
ISI
SICI code
0040-4039(200012)41:51<10095:SOCCPV>2.0.ZU;2-J
Abstract
A simple solid-phase method has been developed, in which Pictet-Spengler cy clization is applied on resin for the synthesis of some conformationally co nstrained tripeptides. This methodology was also used for the synthesis of oxytocin antagonist analogues. (C) 2000 Elsevier Science Ltd. All rights re served.