2,5-Anhydro sugar diacid and 2,5-anhydro sugar diamine based C-2 symmetricpeptidomimetics as potential HIV-1 protease inhibitors

Authors
Chakraborty, TK Ghosh, S Rao, MHVR Kunwar, AC Cho, H Ghosh, AK
Citation
Tk. Chakraborty et al., 2,5-Anhydro sugar diacid and 2,5-anhydro sugar diamine based C-2 symmetricpeptidomimetics as potential HIV-1 protease inhibitors, TETRAHEDR L, 41(51), 2000, pp. 10121-10125
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
51
Year of publication
2000
Pages
10121 - 10125
Database
ISI
SICI code
0040-4039(200012)41:51<10121:2SDA2S>2.0.ZU;2-K
Abstract
Conformationally constrained molecular frameworks of the 2,5-anhydro sugar diacid (9) and 2,5-anhydro sugar diamines (10, 11) were used to construct a rchitecturally beautiful novel C-2 symmetric peptidomimetics 1-8. Although none of these compounds showed any significant HIV-I protease inhibitory ac tivity, further refinements in design may lead to protease inhibitors based on these rigid carbohydrate-derived scaffolds. (C) 2000 Elsevier Science L td. All rights reserved.