The primary aim of postoperative melanoma follow-up is the early detec
tion and treatment of treatable recurrences which gives a survival adv
antage to these patients. The need for follow-up is universally accept
ed. However, there is ongoing controversy about the duration of follow
-up and frequency of reviews. We present a retrospective review of 244
patients with localised thick (greater than or equal to 4.0 mm) cutan
eous melanoma, who had completed a 10-year follow-up or had died from
their melanoma within 10 years. For these criteria, this is the larges
t series of this type which has been reported to date. The incidence o
f treatable recurrences peaked in the first postoperative year at 40%
and then rapidly decreased, levelling off after year 5 at 2.5% per ann
um. We believe that this high incidence of treatable recurrences reinf
orces the need for 10-year follow-up of these patients. We also recomm
end that the annual frequency of follow-up reviews in each year be bas
ed on that year's risk for getting a treatable recurrence. Following t
his principle, we provide an example of such a follow-up programme.