Structure and biosynthesis of human salivary mucins

Authors
Zalewska, A Zwierz, K Zolkowski, K Gindzienski, A
Citation
A. Zalewska et al., Structure and biosynthesis of human salivary mucins, ACT BIOCH P, 47(4), 2000, pp. 1067-1079
Citations number
51
Categorie Soggetti
Biochemistry & Biophysics
Journal title
ACTA BIOCHIMICA POLONICA
ISSN journal
0001527X → ACNP
Volume
47
Issue
4
Year of publication
2000
Pages
1067 - 1079
Database
ISI
SICI code
0001-527X(2000)47:4<1067:SABOHS>2.0.ZU;2-2
Abstract
Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) w ith molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mas s of 200-250 kDa. Monomers of MG1 and MG2 contain havily O-glycosylated tan dem repeats located at the central domain of the molecules. MG1 monomers ar e linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized by mucous cells and MG2 by the serous cells of human sa livary glands.