Estimation or quantification of tumour volume? CT study on irregular phantoms

Purpose: To compare radiologists' subjective size estimation to computerise d volume quantification of tumour-like phantoms in spiral CT. Material and Methods. Eight tubular phantoms with the inside irregularly co vered with silicone (8.7-31.6 ml) were imaged. The phantoms were pairwise c ompared to analyse the differences in silicone volumes. The observers, 2 ra diologists and 2 residents, used both subjective image analysis (2 sessions ) and computerised volume quantification (1 session). Accuracy and observer agreement of both methods were calculated. Results: Subjective size estimation was correct in 51% (mean weighted kappa , kappa (qw)=0.73). Using four observers mean value (kappa (qw)=0.81) or me dian value (kappa (qw)=0.77) slightly improved the results. Average intra-o bserver agreement was better than average interobserver agreement. In compu terised volume quantification 70% of all classifications were correct (mean kappa (qw)=0.85). The results were moderate even when every second or four th slice were measured. Conclusion: Subjective size estimation of irregular rumours should be repea tedly performed by the same observer, or by using the mean or median estima te of several observers. Computer-based methods are even more reliable and their use is especially recommended for film readers with limited radiologi cal experience. Only every fourth slice may be measured without a major los s of measurement accuracy.