B-mode, power Doppler and contrast-enhanced power Doppler ultrasonography in the diagnosis of breast tumors

Purpose: To investigate the role of B-mode and unenhanced and enhanced powe r Doppler ultrasonography (US) in differentiating solid breast lesions, and to find out whether morphologically different tumors differ in terms of va scularity. Material and Method's: Sixty-five lesions, indeterminate or suggestive of m alignancy after mammography were prospectively examined with B-mode and une nhanced and enhanced power Doppler US. The lesions were classified as benig n, indeterminate or malignant at B-mode, and as benign or malignant at powe r Doppler US. The results were compared to the histologic diagnoses. Vascul arity was analyzed also quantitatively to find out whether threshold values for differential diagnostics could be set. Results: The sensitivity, specificity, and overall accuracy of the morpholo gic evaluation were 100%, 10%, and 57%, respectively. Rounded lesions were more vascular than spiculated lesions, but vascular assessment was only hel pful when it supported a benign morphology. In quantitative analysis, due t o the overlap between the benign and malignant lesions, no threshold values could be set. Conclusion: Morphologic criteria were useful in characterizing malignant le sions, but the large proportion of indeterminate findings decreased the spe cificity of US. Neither unenhanced, nor enhanced power Doppler US was able to improve diagnostic accuracy.