Clinicopathologic variants of cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinomas (SCC) are one of the most common maligna ncies, which, with early recognition, may be curable. These tumors represen t a broad spectrum of disorders with many significant clinical, morphologic , and etiologic distinctions. The objective of this article is to review th e important clinicopathologic features of SCC with particular emphasis on i mportant recent developments, practical application, and their relevance to the practice of pathology. The most pertinent literature of the last 5 yea rs was reviewed and capsulized. Appropriate histologic interpretation and c linical management of patients with cutaneous SCC requires a comprehensive understanding of the latest advances in the broad field of dermatopathology . Squamous cell carcinoma of the skin represents a complex group of disease subtypes, each with its own characteristics, which may influence morpholog ic diagnosis as well as treatment and clinical management.