Mass psychogenic illness is characterized by symptoms, occurring among a gr
oup of persons with shared beliefs regarding those symptoms, that suggest o
rganic illness but have no identifiable environmental cause and little clin
ical or laboratory evidence of disease. Mass psychogenic illness typically
affects adolescents or children, groups under stress and females disproport
ionately more than males. Symptoms often follow an environmental trigger or
illness in an index case. They can spread rapidly by apparent visual trans
mission, may be aggravated by a prominent emergency or media response, and
frequently resolve after patients are separated from each other and removed
from the environment in which the outbreak began. Physicians should consid
er this diagnosis when faced with a cluster of unexplained acute illness.