The evaluation of the therapeutic effect of Tao-shang-tsao on alpha-naphthylisothiocyanate and carbon tetrachloride-induced acute liver damage in rats

The hepatoprotective effects of Tao-shang-tsao, hei is laevigatn SCH.-BIP. var, oldhami KITAM., were studied on cholestatic hepatitis induced by alpha -naphthylisothiocyanate (ANIT, 100 mg/10 ml/kg, in olive oil, i.p.) and ac ute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 ml/k g, i.p.) in rats by post-treatment with the crude methanolic extracts of I. laevigata (0.3, 1.0, and 2.0 g/kg) orally in the therapeutic model. Hepato protective activity was monitored by estimating the serum transaminases con centrations and histopathological changes in the livers of experimental rat s. It was found that the I. laevigata extract significantly decreased the a cute elevation of serum transaminases by biochemical examination. According to pathohistological studies in the liver of experimental rats, the crude I. laevigata extract ameliorates the central necrosis, fatty change or prol iferation of bile duct epithelium focal necrosis caused by ANIT or CCl4-ind uced hepatitis rats.