Effect of combined Citrullus colocynthis and Rhazya stricta use in Najdi sheep

The effect of oral administration of 0.25 g/kg/day of Citrullus colocynthis fruits, 0.25 g/kg/day of Rhazya stricta leaves or mixture of the two plant s at 0.25 g/kg/day of C. colocynthis fruits plus 0.25 g/kg/day of R. strict a leaves in Najdi sheep was examined. Or al administration of 0.25 g/kg/day of C. colocynthis fruits or 0.25 g/kg/day of R. stricta leaves for 42 days proved not fatal but that of the mixture of the two plants (0.25 g + 0.25 g/kg/day) proved fatal within 26 days with profuse diarrhea, dehydration, l oss in condition, ataxia and recumbency, prior to death. These manifestatio ns accompanied by enterohepatonephrotoxicity, gelatinization of the renal a nd epicardial fat and transudate in serous cavities were correlated with al terations in serum LDH and AST activities and concentrations of total prote in, albumin, globulin, bilirubin, cholesterol and urea and hematology.