Different etiologies hare been shown to underly lethal midline granuloma, E
vidence of natural killer cell lymphoma is obtained by immunolabeling and m
olecular biology studies. The tumor has a characteristic immunophenotype an
d genotype, This clinicopathological entity is highly associated with Epste
in-Barr virus (EBV). We present the case of a patient with EBV associated w
ith nasal-type natural-killer cell lymphoma and a coexisting hemophagocytic
syndrome.