Reactivation of viral replication after liver resection in patients infected with hepatitis B virus

Objective To investigate the mechanisms and risk factors underlying postoperative rea ctivation of hepatitis after liver resection for hepatitis B virus-related hepatocellular carcinoma. Summary Background Data Although risk factors for acute hepatic failure after liver resection have been reported in patients with chronic liver disease, the issue of reactiva tion of hepatitis B virus replication after liver resection is unresolved. Methods Fifty-five patients with hepatocellular carcinoma and hepatitis B surface a ntigen underwent liver resection. in 25 of these 55 patients, serum levels of hepatitis B virus DNA and the type of hepatitis B virus were determined before and after surgery. Results Postoperative hepatitis occurred in 13 of the 55 patients (24%). Reactivati on of viral replication occurred after liver resection in 7 of the 25 patie nts tested, and alanine aminotransferase activity increased in 6 of these 7 patients. High preoperative alanine aminotransferase activity, high levels of hepatitis B virus DNA, presence of wild-type DNA, and detection of hepa titis B core antigen in hepatocytes, all features of the immune clearance p hase in the natural course of hepatitis B virus infection with no surgery, were more likely to be found in patients with reactivation than in patients without reactivation. Conclusions During the immune clearance phase of hepatitis B virus infection, especiall y the period of acute exacerbation, changes in serum hepatitis B virus DNA level should be monitored for early warnings of reactivation of viral repli cation, likely to cause severe postoperative hepatitis and acute hepatic fa ilure.