Dental caries is the most common infectious disease affecting humans. The p
rincipal causative agents are a group of streptococcal species collectively
referred to as the mutans streptococci of which Streptococcus mutans and S
treptococcus sobrinus are the most important agents of human caries. This r
eview outlines what is currently known about these ubiquitous pathogens and
discusses novel methods for elimination of these bacteria from dental plaq
ue.