Asymmetric bioreduction of an allylic ketosulfone to its corresponding (R)-alcohol

Citation
S. Stahl et al., Asymmetric bioreduction of an allylic ketosulfone to its corresponding (R)-alcohol, BIOCATAL B, 18(6), 2000, pp. 471-477
Citations number
11
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCATALYSIS AND BIOTRANSFORMATION
ISSN journal
10242422 → ACNP
Volume
18
Issue
6
Year of publication
2000
Pages
471 - 477
Database
ISI
SICI code
1024-2422(2000)18:6<471:ABOAAK>2.0.ZU;2-5
Abstract
The screening of 144 microbial strains yielded several suitable biocatalyst s for the asymmetric bioreduction of an allylic ketosulfone to its correspo nding (R)-alcohol. The production of the desired enantiomer with elevated o ptical purity (ee > 90%) was achieved by the yeast strain Candida magnoliae MY 1785. The enantiocomplementary chiral reduction, the production of the (S)-alcohol, was also achieved when employing other microbial strains. The production of preparative amounts (about 2.5 g) of the (R)-enantiomer with elevated optical purity (ee > 90%) was completed when employing the yeast s train Candida magnoliae.