Description of a short-term Taxol (R)-induced nociceptive neuropathy in rats

This work describes a new animal model of neuropathic pain produced by the single intraperitoneal administration of Taxol(R) (32 mg/kg) to male Spragu e-Dawley rats. During the course of the experiment, the clinical status of the rats remained satisfactory and motor function was not altered. A number of classical behavioural tests of nociception as well as histological and electrophysiological investigations were performed. Taxol(R) administration produced an important and rapidly developing mechanical hyperalgesia, a th ermal hypoalgesia but no mechanical or thermal allodynia. Degenerative chan ges were observed in the sciatic nerve, the nerve fibres in the paw subcuta neous tissue and in the lumbar spinal cord. When Taxol(R) or vehicle (a mix of Cremophor and ethanol) were repeatedly injected once a week for 5 weeks , similar nociceptive disorders were observed in addition to a decrease in peripheral nerve conduction velocity. The selective dysfunction of high-dia meter myelinated fibres observed after one single administration of Taxol(R ) (32 mg/kg) may be attributable to paclitaxel-induced neuropathy, however other mechanisms causing neurochemical dysfunction must also be involved. ( C) 2000 Elsevier Science B.V. All rights reserved.