Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain

Authors
Begon, S Pickering, G Eschalier, A Dubray, C
Citation
S. Begon et al., Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain, BRAIN RES, 887(2), 2000, pp. 436-439
Citations number
28
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
887
Issue
2
Year of publication
2000
Pages
436 - 439
Database
ISI
SICI code
0006-8993(200012)887:2<436:MAMHAS>2.0.ZU;2-E
Abstract
Considering that magnesium and non-competitive NMDA receptor antagonists in hibit the opening of the channel linked to the NMDA receptor. we assessed t heir effects on mechanical hyperalgesia in two animal models of neuropathic pain (rats with a sciatic nerve ligature and diabetic rats). Our data show that magnesium reverses the hyperalgesia, as does MK-801. These results su ggest that magnesium could be an alternative for the treatment of neuropath ic pain in patients. (C) 2000 Elsevier Science B.V. All rights reserved.