Expression of bcl-2, bax, bcl-x(L), and bcl-x(S), in endometrial and cervical tissues

We assessed the protein expression levels of bcl-2, bax, bcl-x(L), and bcl- x(S) in a group of 51 endometrial cancers and 8 normal samples as well as i n 59 cervical neoplasms and in 15 normal cervical tissues. Neoplastic endom etria (median, 1.30 absorbance units [AU]; range, 0.13-7.26 AU) had slightl y higher bcl-2 levels than did normal tissue (median, 0.83 AU; range, 0.29- 1.90 AU; P <.068), whereas bcl-2 was lower in neoplastic (median, 3.59 AU; range, 0.13-19.86 AU) than in normal cervical samples (median, 8.45 AU; ran ge, 2.09-15.04 AU; P <.010). Bcl-x(L) levels were higher in endometrial car cinoma (median, 1.23 AU; range, 0.03-4.29 AU) than in normal tissues (media n, 0.56 AU; range, 0.46-1.48 AU; P <.048), whereas no significant differenc e was observed in cervical tissues. Bax levels did not show any variation i n either system. The protein bel-x, was marginally detectable in only a few samples. In endometrial carcinoma, bcl-2 and bcl-x(L) levels were correlat ed inversely (r = -0.27; P <.054), whereas in cervical cancer, they were co rrelated directly (r = +0.40; P <.002). The different expression patterns o f bcl-2 family members in endometrial and cervical tissues confirm the hypo thesis of a strictly tissue-specific regulation of these proteins.