Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21)
H. Sjogren et al., Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21), CANCER RES, 60(24), 2000, pp. 6832-6835
Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by recurrent
t(9;22) or t(9;17) translocations resulting in fusions of the NH2-terminal
transactivation domains of EWS or TAF2N to the entire TEC protein. We repor
t here an EMC with a novel translocation t(9; 15)(q22;q21) and a third type
of TEC-containing fusion gene. The chimeric transcript encodes a protein i
n which the first 108 amino acids of the NH2-terminus of the basic helix-lo
op-helix (bHLH) protein TCF12 is linked to the entire TEC protein. The tran
slocation separates the NH2-terminal domain of TCF12 from the bHLH domain a
s well as from a potential leucine zipper domain located immediately downst
ream of the breakpoint. These results demonstrate that the NH2-terminal tra
nsactivation domains of EWS or TAF2N are not unique in their ability to con
vert the TEC protein into an oncogenically active fusion protein, and that
they may be replaced by a domain from a bHLH protein that presumably endows
the fusion protein with similar functions.