A mannose-6-phosphonate-cholesterylamine conjugate as a specific molecularadhesive linking cancer cells with vesicles

Authors
Barragan, V Menger, FM Caran, KL Vidil, C Morere, A Montero, JL
Citation
V. Barragan et al., A mannose-6-phosphonate-cholesterylamine conjugate as a specific molecularadhesive linking cancer cells with vesicles, CHEM COMMUN, (01), 2001, pp. 85-86
Citations number
13
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
01
Year of publication
2001
Pages
85 - 86
Database
ISI
SICI code
1359-7345(2001):01<85:AMCAAS>2.0.ZU;2-R
Abstract
A hydrolytically stable sugar phosphonate coupled to a steroid via a long a nd semi-rigid spacer (synthesized via a 12-step sequence) binds both to the mannose-6-phosphonate receptors of certain cancer cells and to the lipid b ilayer of vesicles, thereby serving as a multivalent adhesive between cell and vesicle surfaces.