Palladium-catalyzed coupling reaction of fluoroalkylated propargyl mesylates with organozinc reagents: Novel synthesis of optically active fluorine-containing trisubstituted allenes
T. Konno et al., Palladium-catalyzed coupling reaction of fluoroalkylated propargyl mesylates with organozinc reagents: Novel synthesis of optically active fluorine-containing trisubstituted allenes, CHEM LETT, (12), 2000, pp. 1360-1361
In the presence of 5 mol% of tetrakis(triphenylphosphine)palladium(0). the
reaction of chiral fluorinated propargyl mesylates with a variety of organo
zinc reagents proceeded smoothly in a highly stereoselective fashion to giv
e the corresponding optically active fluorine-containing trisubstituted all
enes in good yields without any loss of optical purity through the reaction
.