A. Kirschning et al., The "resin-capture-release" hybrid technique: A merger between solid- and solution-phase synthesis, CHEM-EUR J, 6(24), 2000, pp. 4445-4450
A polymer-assisted organic synthesis that combines the concept of solid-pha
se synthesis with the idea of polymer-supported scavenging reagents has rec
ently appeared on the chemistry scene. This technique has frequently been t
ermed the "resin-capture-release" methodology and is initiated by the immob
ilization of a small molecule on a polymeric support. This intermediate is
subjected to a second transformation by adding a new reaction partner in so
lution. This reactant plays two roles: a) the chemical alteration of the po
lymer-bound intermediate and b) the simultaneous release of this reaction p
roduct from the resin back into solution. This new concept is presented and
future prospects are discussed.