The "resin-capture-release" hybrid technique: A merger between solid- and solution-phase synthesis

A polymer-assisted organic synthesis that combines the concept of solid-pha se synthesis with the idea of polymer-supported scavenging reagents has rec ently appeared on the chemistry scene. This technique has frequently been t ermed the "resin-capture-release" methodology and is initiated by the immob ilization of a small molecule on a polymeric support. This intermediate is subjected to a second transformation by adding a new reaction partner in so lution. This reactant plays two roles: a) the chemical alteration of the po lymer-bound intermediate and b) the simultaneous release of this reaction p roduct from the resin back into solution. This new concept is presented and future prospects are discussed.